The incident happened on the Eastern Freeway between junction 11 for Birchwood and junction 12 for the Eccles Interchange at around 8.10am this morning.
A Greater Manchester Police spokesman said: “Injury only road traffic collision at 8.10am this morning, lorry and car.”
The collision caused all traffic to be temporarily backed up, causing long queues and delays throughout the morning.
A spokesman for National Highways said: “Eastbound traffic was initially held up following an incident around junction 12 just before 9am.
“The motorway was completely closed, with emergency services on the scene.”
The road was later partially reopened, but delays continued until traffic returned to normal shortly before 11am.
No injuries were reported.